Desflurane and sevoflurane differentially affect activity of the subthalamic nucleus in Parkinson's disease

BackgroundDesflurane and sevoflurane are commonly used during inhalational anaesthesia, but few studies have investigated their effects on deep cerebral neuronal activity. In addition, the association between subthalamic nucleus (STN) neurophysiology general anaesthesia induced by volatile anaesthetics not yet identified. This study aimed to identify differences in neurophysiological characteristics of STN comparable minimal alveolar concentration (MAC) desflurane for brain stimulation (DBS) patients with Parkinson's disease.MethodsTwelve similar disease severity received (n=6) or DBS surgery. We obtained spike firing using microelectrode recording at 0.5–0.6 MAC compared rate, power spectral density, coherence.ResultsNeuronal rate was lower (47.4 [26.7] Hz) than (63.9 [36.5] (P<0.001). Sevo?urane entrained greater gamma oscillation (62.9% [0.9%] vs 57.0% [1.5%], respectively; P=0.002). There coherence theta band group (13% 6%, respectively). Anaesthetic choice did differentially influence mapping accuracy clinical outcome electrode implantation.ConclusionsDesflurane produced distinct profiles humans that may be associated analgesic hypnotic actions.